As a result, a wide variety of side effects are possible. In addition, DHEA has not been tested or widely used over a long period of time, so it is not clear what the long-term effects might be.
Because 7-keto-DHEA is not converted to steroid hormones by the body, the risk of some of the hormonal side effects is reduced. Although 7-keto-DHEA has been promoted as assisting in weight-loss, building muscle and stimulating the immune system, evidence supporting any of these claims is limited. Medications often interact with each other. DHEA has a complex role, and a range of interactions can occur when using it with other medications.
Special caution is needed when using DHEA alongside any of the following drugs or substances:. DHEA must be avoided with testosterone therapy, as it can lead to a low sperm count and enlarged breasts in men and in male characteristics in women. People with the following risks or conditions should be especially careful when considering DHEA:. DHEA supplements should not be taken during pregnancy or while breastfeeding.
Children should not use it. DHEA is a complicated chemical with many roles. In the future, it may be used in a variety of treatment. For now, however, it is best to be cautious when using it, as there is a lack of evidence regarding its safety and effectiveness.
A range of DHEA supplements are available for purchase online. Phytoestrogens are a natural compound found in plants. When eaten, they may affect a person in the same way as estrogen produced by the body.
Meldonium is perhaps most well-known for its role in sports doping. This article will explore the story of its origin and its broad medical uses in…. Testosterone is a sex hormone that regulates sexual development, muscle mass, and red blood cell production. It originates mainly in the testicles and…. Many athletes turn to caffeine as a way of boosting their performance, but a new study suggests that regular caffeine intake may have the opposite…. How can DHEA benefit your health?
Medically reviewed by Alan Carter, Pharm. What is DHEA? Naturally raising levels Medical use Side effects Drug interactions Risks We include products we think are useful for our readers. What is dehydroepiandrosterone DHEA? Share on Pinterest DHEA is naturally produced by the body but supplements are also synthetically made in labs. DHEA and the brain. Naturally raising levels of DHEA.
Medical uses. Share on Pinterest Athletes sometimes use DHEA to build muscle strength, but there is a lack of evidence to support this use. Side effects. Drug interactions. It is important to ask for professional advice before using it. Latest news Scientists identify new cause of vascular injury in type 2 diabetes. Adolescent depression: Could school screening help?
Something went wrong on our side, please try again. Show references DHEA. Natural Medicines. Accessed Jan. Pizzorono JE, et al. Dehydroepiandrosterone DHEA. In: Textbook of Natural Medicine. Elsevier; IBM Micromedex. Kellerman RD, et al. Popular herbs and nutritional supplements. In: Conn's Current Therapy The National Collegiate Athletic Association. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.
Legal Conditions and Terms Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Advertising Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Advertising and sponsorship policy Advertising and sponsorship opportunities.
Reprint Permissions A single copy of these materials may be reprinted for noncommercial personal use only. The dose of DHEA may depend on a person's gender, age, and condition. Laboratory tests can assess your DHEA levels before you take it, and can monitor levels after you start. Talk to your doctor to find the right dose for you. Higher doses have been used to treat lupus. People with lupus should not take DHEA without first talking to their doctor. Because of the potential for side effects and interactions with medications, dietary supplements should be taken only under the supervision of a knowledgeable health care provider.
People under 40 shouldn't take DHEA unless they have low levels as determined by their doctors. People taking DHEA should have their blood levels checked every 6 months. Because your body uses DHEA to make estrogen and testosterone, people with hormone-related cancers, such as breast, prostate, ovarian, adrenal, and testicular cancer, or a family history of these cancers, should not take DHEA. DHEA may make other hormone-related conditions, such as endometriosis or polycystic ovarian syndrome, worse.
Some experts think people with a history of depression or bipolar disorder may have side effects from using DHEA including mania and irritability. High doses of DHEA may prompt the body to stop making the hormone. High doses may also be toxic to liver cells. At least one case of hepatitis has been reported. People who have liver disease should avoid DHEA. Some experts are concerned that DHEA may make liver problems worse.
DHEA may increase the production of the male hormone testosterone. Women should be aware of the risk of developing signs of masculinization. These include loss of hair on the head, deepening of the voice, growth of hair on the face, weight gain around the waist, or acne.
Men should be aware of the risks of too much testosterone, such as shrinkage of the testicles, aggression, male pattern baldness, high blood pressure, and possible higher risk for testosterone-related cancers. Call your doctor if any of these symptoms occur. If you are currently being treated with any of the following medications, or with any medications designed to alter the levels or metabolism of various hormones in your body, you should not use DHEA without talking to your doctor first.
However, researchers don't know if that would be true or safe in humans. Animal studies suggest that DHEA may strengthen the effects of barbiturates, a sedative often used to treat sleep disorders. These medicines include butabarbital, mephobarbital, pentobarbital, and phenobarbital. Laboratory studies suggest that DHEA may increase the effects of prednisolone, used to treat inflammation and other disorders.
DHEA may affect levels of estrogen and testosterone in the body. People who are taking hormone therapy should talk to their doctors to see if their doses need to be adjusted. DHEA may make insulin and drugs used to lower blood sugar less effective, raising the risk of high blood sugar.
Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study. Psychopharmacology Berl. Patients with refractory Crohn's disease or ulcerative colitis respond to dehydroepiandrosterone: a pilot study.
Aliment Pharmacol Ther. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med. Barad DH, Gleicher N. Increased oocyte production after treatment with dehydroepiandrosterone. Fertil Steril. The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. J Clin Endocrinol Metab.
Dehydroepiandrosterone in systemic lupus erythematosus: relationship between dosage, serum levels, and clinical response. J Rheumatol. Baulieu EE.
Thomas G, Legrain S, et al. Dehydroepiandrosterone treatment effects on weight, bone density, bone metabolism and mood in women suffering from anorexia nervosa - a pilot study. Psychiatry Res. The Andro Project: Physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program.
Arch Intern Med. Corrigan AB. Dehydroepiandrosterone and sport. Med J Aust. Blood and tissue dehydroepiandrosterone sulphate levels and their relationship to chronic inflammatory bowel disease. Clin Exp Rheumatol. An open-label dose-escalation trial of oral dehydroepiandrosterone tolerance and pharmacokinetics in patients with HIV disease. J Acquir Immune Defic Syndr.
A randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgia. Dehydroepiandrosterone replacement in aging humans.
J Clin Endocrinol Metabol. Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women. Differential effect of oral dehydroepiandrosterone-sulfate on metabolic syndrome features in pre- and postmenopausal obese women. Clin Endocrinol Oxf. Changes in bone turnover markers and menstrual function after short-term oral DHEA in young women with anorexia nervosa.
J Bone Miner Res. Dehydroepiandrosterone DHEA supplementation for cognitive function in healthy elderly people.
Cochrane Database Syst Rev. DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet. Am J Physiol.
DHEA deficiency syndrome: a new term for old age? J Endocrinol. Chemotherapy of murine colorectal carcinoma with cisplatin and cisplatin plus 3'- deoxy-3'- azidothymidine. Anticancer Res. Ingestion of a dietary supplement containing dehydroepiandrosterone DHEA and androstenedione has minimal effect on immune function in middle-aged men. J Am Coll Nutr. J Affect Disord. Labrie F.
0コメント